Drug Name
Vein Support

Drug Uses
Vein Support contains DiosVein, a form of the flavonoid diosmin, which has been used for over thirty years as a vascular-supportive agent in Europe.

How to use
Take one capsule two times daily. For optimal absorption, take with a fat-containing meal or snack.

Drug Class and Mechanism
DiosVein is derived from sweet orange and is a rich source of bioflavonoids. Clinical studies conducted in Europe have shown DiosVein to be particularly effective at supporting the health of blood vessels and promoting normal circulatory function. Further clinical trials have found that diosmin used in combination with the flavonoid hesperidin supports healthy venous function.

Diosmin has numerous beneficial effects on blood vessels and circulation. These effects include enhancing venous tone, supporting lymphatic drainage, promoting the health of cells comprising the blood vessel lining and supporting normal, but not excessive, capillary permeability. Flavonoids in general may support vessel health by preventing the abnormal synthesis of prostaglandins and related mediators, or by blocking the adverse effects of these substances on venous tissue.

Vein Support also features natural vitamin K2, a form of K2 found in the traditional Japanese fermented food, natto. Recent studies highlight the importance of adequate vitamin K2 levels for healthy blood vessel function. It is a long-acting form of vitamin K2that has been shown to support cardiovascular health.

The major role for vitamin K2 seems to be its ability to activate a protein present in blood vessels known as Matrix Gla Protein (MGP). MGP is thought to be responsible for venous remodeling and is known to act as an inhibitor of vessel calcification as shown in mice studies. Further studies in rats show that administration of substances that antagonize (or oppose) the normal effects of vitamin K2, and thus inhibit the proper activation of MGP, also significantly and rapidly leads to vessel calcification.

Missed Dose
If you miss a dose of Vein Support, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage
Store Vein Support at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Vein Support out of the reach of children and away from pets.

Warnings/Precautions
There are no known warnings or precautions for Vein Support usage.

Possible Side Effects
Vein Support is not known to have any side effects if taken as per the prescribed dosage.

More Information
Two smaller studies conducted as double-blind placebo-controlled investigations assessed the impact of 500 mg of the flavonoid combination (consisting of diosmin and hesperidin) taken daily on enhancement of venous function (Ramelet 2005). In the first study, 40 participants with compromised venous function were divided into a treatment and placebo arm. Global improvement scores were calculated for various clinical parameters of venous health. The participants in the treatment group supplementing with 500 mg of the combination showed significantly greater enhancements in venous function after two months of therapy compared to participants in the placebo group. A second double blind, placebo-controlled investigation conducted in 160 individuals also showed beneficial effects. In this study, individuals were divided into a placebo group and a treatment group supplementing with 500 mg of the flavonoid combination twice daily (1000 mg total per day) for eight weeks. Evaluation of change in venous parameters was the endpoint of this study. The results of this investigation concluded that individuals taking the flavonoid supplement had significant improvements in venous health when compared with the participants in the placebo arm of the study. Both studies confirmed the beneficial influences of these flavonoids on endothelial health and venous function.